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MCF-7 cells, a human breast carcinoma line, forms tumors when injected into athymic nude mice. These tumors are able to metastasize to lungs, liver and spleen. Castration or diabetes prevents metastasis formation, but treatment with estrogen or insulin restores the metastasizing capacity.
Estrogen or insulin addition to the culture enhances collagenase production. Attention is called to the coexistence of enhancement in collagenase production and metastasis formation. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. Search: Search. Advanced Clipboard. Display options Display options. Create file Cancel. citation Subject: 1 selected item: - PubMed. Format: Summary Summary text Abstract Abstract text.
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Osborne CK, et al. Cancer Res. Metastasis of human tumors in athymic nude mice. Sharkey FE, Fogh J. Sharkey FE, et al. Int J Cancer. Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cos S, et al. Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives. Van Roy F, et al. See all similar articles. Cheng JN, et al. Clin Exp Metastasis.
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Barney LE, et al. Integr Biol Camb. See all "Cited by" articles.
MeSH terms Animals Actions. Castration Actions. Cell Line Actions.
Female Actions. Humans Actions. Mice Actions.
Mice, Nude Actions. Streptozocin Actions. Substances Insulin Actions. Estradiol Actions. Full text links [x] Elsevier Science. Copy Download.Boobies nudes
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Formation of metastasis by human breast carcinoma cells (MCF-7) in nude mice